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Frozen Anaplasma centrale-infective bovine blood for
the immunisation of cattle against anaplasmosis
(Anaplasma marginale) infection.
Frozen
anaplasmosis vaccine may only be kept on dry ice or in
liquid nitrogen
(temperatures below -70°ßC). An ordinary household
freezer (-18°ßC) is not suitable
for storage of this vaccine. Vaccine, which on receipt
is completely thawed, is ineffective
and must not be used. Frozen vaccine removed from storage
(liquid nitrogen/dry ice)
will thaw slowly when put on melting ice. If kept on melting
ice it will be suitable for
use for a maximum period of 4 hours. Thawed vaccine cannot
be refrozen for later
use.
RECOMMENDATIONS FOR USE
CALVES:
In those areas of the country where anaplasmosis occurs,
all calves should be vaccinated at approximately
6 months of age (between 3 and 9 months). This age group
shows only mild reactions which normally
require no treatment, but daily supervision during the
expected reaction period is strongly recommended.
ADULT CATTLE:
The natural resistance exhibited by calves against the
disease gradually diminishes with age. Therefore,
vaccination of adult animals should be approached with
caution.
In view of possible reactions in older animals, only as
many animals as can be handled with ease, should
be immunised at any given time.
The vaccine reactions may cause anaemia and fever. Avoid
subjecting animals to any form of stress,
such as rough handling or driving them over long distances
during the expected reaction period.
Under normal circumstances only a single vaccination is
sufficient.
Anaplasmosis vaccine may also safely be administered together
with any other vaccine, except
heartwater.
WARNINGS
Do
not slaughter animals for human consumption within 7 days
of vaccination.
Vaccinate healthy animals only.
Keep out of reach of children, uninformed persons and
animals.
Anaplasmosis vaccine is not completely innocuous. Some
vaccinated adult cattle develop
typical anaplasmosis reactions and may even die if they
are not promptly treated as
prescribed. The reactions are, however, mild in comparison
with those of natural
anaplasmosis infections.
Pregnant cows may abort and should therefore be vaccinated
only after calving.
Although this product has been extensively tested under
a wide range of conditions,
failure thereof may ensue as a result of a number of reasons.
If this is suspected, seek
veterinary advice and notify the registration holder.
DIRECTIONS FOR USE
Use
only as directed.
Depending on the facilities available for storage and
transport of the frozen vaccine, one of the following
methods can be used:
Rapid thawing (Vaccine remains effective for 30 minutes):
• Take the vaccine in the frozen state on dry ice
or in liquid nitrogen to the work area.
• Muster
the correct number of cattle before thawing the
vaccine.
• Thaw the vaccine rapidly
in lukewarm water (40 °C, approximately body temperature).
Gentle agitation of the vaccine bottle will reduce the
thawing time to approximately 5 minutes.
• Thaw
sufficient vaccine only for immediate administration.
• If any delay is experienced during vaccination,
the thawed vaccine may be placed on melting
ice
for a maximum period of 30 minutes before
administration.
Slow thawing (Vaccine
remains effective for 4 hours):
• Frozen
vaccine may be removed from storage (liquid nitrogen/dry
ice) and put on melting ice and
then transported to the work area.
• The vaccine
will thaw slowly on melting ice, and
if kept on melting ice (provided that an excess
of ice is constantly present in the container) it will
be suitable for use for a maximum period of
4 hours after removal from liquid nitrogen
or dry ice.
Sterilise needles and syringes by boiling in water for
a least 15 minutes. Do not use disinfectants or
methylated spirits for sterilising either syringes or
needles. Preferably use a separate needle for each
animal.
DOSAGE: 1 ml intramuscularly,
irrespective of age or body mass.
EFFECTS
OF THE VACCINE AND TREATMENT OF REACTION
The anaplasmosis vaccine reactions usually set in from
the 4 th to the 6 th week after inoculation and
last for approximately 2 weeks. During this period animals
should be watched closely for clinical signs
of anaplasmosis. The peak of the reaction may be accompanied
by fever (40 °C or higher) and symptoms
such as poor appetite, decreased milk production, constipation,
anaemia and jaundice.
Animals showing severe reactions must be treated with
one of the injectable tetracycline antibiotics without
delay to prevent possible deaths. A single treatment at
10 mg per kg body mass is usually sufficient to control
the reaction, but a second treatment will not adversely
affect the development of immunity. In some cases additional
supportive therapy may be necessary and in these cases
veterinary advice is recommended.
Some animals may take longer to react, but on average
all cattle should have developed immunity 2
months after vaccination. In anaplasmosis areas where
vaccinated cattle are exposed to infected ticks,
they will develop life-long immunity. However, immunity
cannot be guaranteed in all animals.
PACKING
Available in bottles of 5 doses. |
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